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The laboratory aims to develop portable point-of-care pathogen DNA detection devices to meet the detection needs of microorganisms such as infectious viruses and bacteria. Core technologies cover multiple fields, including thermal control technology, circuit design, precision processing, sensing technology, biological sample processing, and image analysis.











In terms of thermal control technology, we develop efficient thermal control systems to ensure temperature stability during sample processing, ensuring the accuracy and reliability of test results.


Regarding circuit design, we design sophisticated circuits to support various device functions while ensuring stable operation under different conditions.


Precision machining is used to manufacture various device components, ensuring high accuracy and reliability.

The development of sensing technology enables devices to quickly and sensitively detect the presence of microorganisms and accurately record the detection results.


Regarding biological sample processing and image analysis, we develop efficient biological sample processing technology to ensure that the sample preparation process meets the detection standards. At the same time, we use image analysis technology to interpret the test results and convert them into a form that users can understand.





We aim to make the detection of microorganisms, such as infectious viruses and bacteria, more convenient and practical. The device can detect in any field and transmit the detection results to the cloud database for further analysis through IoT technology, thereby providing more valuable information to relevant academic circles and institutions.




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創想CR-10S 300








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Sheu, S. C., Kijamnajsuk, P., Chan, C. K., & Chen, J. J.* A 3D-printed oscillatory polymerase chain reaction system using a single heater. Applied Thermal Engineering, 239, 122201. (SCI IF=6.465, Cited number=0, Energy - Energy Engineering and Power Technology Q1) (MOST NSTC 112-2637-B-020-004-)



Thairat, C., Kijamnajsuk, P., Chotikaprakhan, S., Kuleung, C., & Chen, J. J. Development of real-time fluorescence CRISPRCas12a-based detection as a portable diagnostic system using integrated circuits. Applied Science and Engineering Progress, 11(1), 1-13. (Scopus)



Sheu, S. C., Song, Y. S., & Chen, J. J.* A portable continuous-flow polymerase chain reaction chip device integrated with arduino boards for detecting colla corii asini. Micromachines, 13(8), 1289. (SCI IF=3.523, Cited number=2, Engineering - Electrical and Electronic Engineering Q2) (MOST 110-2313-B-020-003-)


Chen, J. J.*, & Lin, Z. H. Fabrication of an oscillating thermocycler to analyze the canine distemper virus by utilizing reverse transcription polymerase chain reaction. Micromachines, 13(4), 600. (SCI IF=3.523, Cited number=5, Engineering - Electrical and Electronic Engineering Q2) (MOST 109-2313-B-020-008-)


Sheu, S, C., Huang, C, Y., & Chen, J. J.* Portable molecular diagnostics device for identification of Asini Corii Colla by loop-mediated isothermal amplification. Inventions, 6(3), 51.(MOST 109-2313-B-020-008-)


Huang, H. J., Chiang, Y. C., Hsu, C. H., Chen, J. J., Shiao, M. H., Yeh, C. C., Huang, S. L., & Lin, Y. S.* Light energy conversion surface with gold dendritic nanoforests/Si chip for plasmonic polymerase chain reaction. Sensors, 20(5), 1293. (SCI Impact Factor=3.275, INSTRUMENTS & INSTRUMENTATION Q1)


Ma, S. Y., Chiang, Y. C., Hsu, C. H., Chen, J. J., Hsu, C. C., Chao, A. C., & Lin, Y. S.* Peanut detection using droplet microfluidic polymerase chain reaction device. Journal of Sensors, 2019. (SCI Impact Factor=1.595, Cited number=0/0 (0), INSTRUMENTS & INSTRUMENTATION Q3)


Chen, J. J.*, & Li, K. Analysis of PCR kinetics inside a microfluidic DNA amplification system. Micromachines, 9(2), 48. (SCI Impact Factor=2.523, Cited number=0/0 (0), NANOSCIENCE & NANOTECHNOLOGY Q3, INSTRUMENTS & INSTRUMENTATION Q2)(MOST 106-2313-B-020-006-MY2)


Chen, J. J.*, & Hsieh, I. H. Using an IR lamp to perform DNA amplifications on an oscillatory thermocycler. Applied Thermal Engineering, 106, 1-12. (SCI Impact Factor=4.725, Cited number=0/0 (0), THERMODYNAMICS Q1, ENERGY & FUELS Q2, ENGINEERING, MECHANICAL Q1, MECHANICS Q1)(MOST 104-2313-B-020-001-)

Chen, J. J.*, Chen, W. H., & Liu, H. J. Oscillatory-type DNA amplification system with 8051 based temperature controller. Journal of Mechanical Engineering and Automation, 6(2), 25-29. (MOST 104-2313-B-020-001-, MOST 104-2627-B-020-001-)

Chen, J. J.*, Sheu, T. S., & Wang, Y. J. Continuous-flow DNA amplification device employing microheaters. In Defect and Diffusion Forum (Vol. 366, pp. 17-30). Trans Tech Publications. (EI, JA, Cited number=0/0 (1))(MOST 104-2313-B-020-001-)


Chen, J. J.*, Liao, M. H., Li, K. T., & Shen, C. M. One-heater flow-through polymerase chain reaction device by heat pipes cooling. Biomicrofluidics, 9(1), 014107. (SCI Impact Factor=2.5, Cited number=0/0 (9), BIOCHEMICAL RESEARCH METHODS Q3, BIOPHYSICS Q3, NANOSCIENCE & NANOTECHNOLOGY Q3, PHYSICS, FLUIDS & PLASMAS Q2)(MOST 103-2313-B-020-006-)


Chen, J. J.*, Li, K., Chen, W., & Yang, Y. Analysis of thermal performance in a bidirectional thermocycler by including thermal contact characteristics. Micromachines, 5(4), 1445-1468. (SCI Impact Factor=2.523, Cited number=0/0 (0), NANOSCIENCE & NANOTECHNOLOGY Q3, INSTRUMENTS & INSTRUMENTATION Q2)(MOST 103-2313-B-020-006-)

Chen, J. J.*, Yang, F. H., & Liao, M. H. PTFE capillary-based DNA amplification within an oscillatory thermal cycling device. World Academy of Science, Engineering and Technology, International Journal of Mechanical, Aerospace, Industrial, Mechatronic and Manufacturing Engineering, 8(7), 1181-1185. (NSC 102-2313-B-020-011-)

Chen, J. J.*, Liao, S., Liu, M., Lin, J., Sheu, T., & Miao, M. Surface tension flows inside surfactant-added poly (dimethylsiloxane) microstructures with velocity-dependent contact angles. Micromachines, 5(2), 116-138. (SCI Impact Factor=2.523, Cited number=0/0 (0), NANOSCIENCE & NANOTECHNOLOGY Q3, INSTRUMENTS & INSTRUMENTATION Q2)(NSC 102-2313-B-020-011-)


Chen, S. J., & Chen, J. J.* Design and microfabrication of a high throughput thermal cycling platform with various annealing temperatures. In Proceedings of World Academy of Science, Engineering and Technology (No. 75, p. 434). World Academy of Science, Engineering and Technology (WASET). (NSC 101-2313-B-020-023-)

Chen, J. J.*, Shen, C. M., & Ko, Y. W. Analytical study of a microfludic DNA amplification chip using water cooling effect. Biomedical Microdevices, 15(2), 261-278. (SCI Impact Factor=2.176, Cited number=2/6 (16/22), ENGINEERING, BIOMEDICAL Q3, NANOSCIENCE & NANOTECHNOLOGY Q3)(NSC 100-2221-E-020-024-)

Chen, J. J.*, Chen, W. H., & Shie, Y. S. The effect of thermal contact resistance on heat management in a shuttling PCR system. In Applied Mechanics and Materials (Vol. 284, pp. 1941-1945). Trans Tech Publications. (EI, CA)(Cited number=0/0 (1))(NSC 100-2221-E-020-024-)


Sheu, T. S., Chen, S. J., & Chen, J. J.* Mixing of a split and recombine micromixer with tapered curved microchannels. Chemical Engineering Science, 71, 321-332. (SCI Impact Factor=4.311, Cited number=44, ENGINEERING, CHEMICAL Q1)(NSC 100-2221-E-020-024-)

Chen, J. J.*, & Shie, Y. S. Interfacial configurations and mixing performances of fluids in staggered curved-channel micromixers. Microsystem technologies, 18(11), 1823-1833. (SCI Impact Factor=1.737, Cited number=0/2 (10), ENGINEERING, ELECTRICAL & ELECTRONIC Q3, NANOSCIENCE & NANOTECHNOLOGY Q4, MATERIALS SCIENCE, MULTIDISCIPLINARY Q3, PHYSICS, APPLIED Q3)(NSC 100-2221-E-020-024-)


Chen, J. J.*, & Yang, Y. T. Modeling and experiment of shuttling speed effects on the OSTRYCH. Applied Thermal Engineering, 31(14-15), 2797-2807. (SCI Impact Factor=4.725, Cited number=0/0 (0), THERMODYNAMICS Q1, ENERGY & FUELS Q2, ENGINEERING, MECHANICAL Q1, MECHANICS Q1)(NSC 99-2313-B-020-009)

Chen, J. J.*, Chen, C. H., & Shie, S. R. Optimal designs of staggered Dean vortex micromixers. International Journal of Molecular Sciences, 12(6), 3500-3524. (SCI Impact Factor=4.556, Cited number=2/5 (7/10), BIOCHEMISTRY & MOLECULAR BIOLOGY Q1, CHEMISTRY, MULTIDISCIPLINARY Q2)(NSC 99-2313-B-020-009)

Chen, J. J.*, & Chen, C. H. Investigation of swirling flows in mixing chambers. Modelling and Simulation in Engineering, 2011, 10. (Scopus)(Cited number=0/0 (3))(NSC 96-2221-E-020-021-)

Chen, J. J.*, Lai, Y. R., Tsai, R. T., Der Lin, J., & Wu, C. Y. Crosswise ridge micromixers with split and recombination helical flows. Chemical Engineering Science, 66(10), 2164-2176. (SCI Impact Factor=4.311, Cited number=28, ENGINEERING, CHEMICAL Q1)(NSC 96-2221-E-020-021-)


Hsieh, T. Y., & Chen, J. J.* Simulation and design of the geometric characteristics of the oscillatory thermal cycler. Engineering Technology, 29, 295-303. (Cited number=0/0 (3))(NSC 97-2221-E-020-034-)

Lu, C. S., Chen, J. J.*, Liau, J. H., & Hsieh, T. Y. Flow and concentration analysis inside a microchannel with lightning grooves at two floors. Journal of Biomechatronics Engineering, 2(1), 13-32. (Cited number=0/0 (1))(NSC 97-2221-E-020-034-)


Chen, J. J.*, Liu, W. Z., Lin, J. D., & Wu, J. W. Analysis of filling of an oval disk-shaped chamber with microfluidic flows. Sensors and Actuators A: Physical, 132(2), 597-606. (SCI Impact Factor=2.904, Cited number=1/4 (10), ENGINEERING, ELECTRICAL & ELECTRONIC Q2, INSTRUMENTS & INSTRUMENTATION Q2)


Chen, J. J.*, & Lin, J. D. A theoretical model for the nongray radiation drying of polyvinylalcohol/water solutions. Drying Technology, 22(4), 853-875. (SCI Impact Factor=2.988, Cited number=0/2 (2), ENGINEERING, CHEMICAL Q2, ENGINEERING, MECHANICAL Q2)


Chen, J. J., & Lin, J. D.* Thermocapillary effect on drying of a polymer solution under non-uniform radiant heating. International Journal of Heat and Mass Transfer, 43(12), 2155-2175. (SCI Impact Factor=4.947, Cited number=0/12 (21), THERMODYNAMICS Q1, ENGINEERING, MECHANICAL Q1, MECHANICS Q1)


Chen, J. J., Lin, J. D.*, & Sheu, L. J. Simultaneous measurement of spectral optical properties and thickness of an absorbing thin film on a substrate. Thin Solid Films, 354(1-2), 176-186. (SCI Impact Factor=2.03, Cited number=1/9 (20), MATERIALS SCIENCE, MULTIDISCIPLINARY Q3, MATERIALS SCIENCE, COATINGS & FILMS Q3, PHYSICS, APPLIED Q3, PHYSICS, CONDENSED MATTER Q3)


Chen, J. J., & Lin, J. D.* Simultaneous heat and mass transfer in polymer solutions exposed to intermittent infrared radiation heating. Numerical Heat Transfer, Part A Applications, 33(8), 851-873. (SCI Impact Factor=2.96, Cited number=3/7 (7), THERMODYNAMICS Q1, MECHANICS Q2)​

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